Time-resolved fluorescence spectroscopy of human brain tumors

Laura Marcu; Reid C. Thompson; Smita Garde; Mark Sedrak; Keith L. Black; William H. Yong

doi:10.1117/12.465244

1 May 2002 Time-resolved fluorescence spectroscopy of human brain tumors

Laura Marcu, Reid C. Thompson, Smita Garde, Mark Sedrak, Keith L. Black, William H. Yong

Proceedings Volume 4613, Optical Biopsy IV; (2002) https://doi.org/10.1117/12.465244
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Fluorescence spectroscopy of the endogenous emission of brain tumors has been researched as a potentially important method for the intraoperative localization of brain tumor margins. In this study, we investigate the use of time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) for demarcation of primary brain tumors by studying the time-resolved spectra of gliomas of different histologic grades. Time-resolved fluorescence (3 ns, 337 nm excitation) from excised human brain tumor show differences between the time-resolved emission of malignant glioma and normal brain tissue (gray and white matter). Our findings suggest that brain tumors can be differentiated from normal brain tissue based upon unique time-resolved fluorescence signature.

Citation Download Citation

Laura Marcu, Reid C. Thompson, Smita Garde, Mark Sedrak, Keith L. Black, and William H. Yong "Time-resolved fluorescence spectroscopy of human brain tumors", Proc. SPIE 4613, Optical Biopsy IV, (1 May 2002); https://doi.org/10.1117/12.465244

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