Histological study of hamster buccal mucosa following topical application of DMBA and exposition to low-power 337-nm laser light

Christmas M. V. de Barros Rego; Egberto Munin; Marcela Leal Redigolo; Miguel Castilho Salgado; Hanriete P. de Souza; C. E. D. Colombo; Renata Amadei Nicolau; Leandro Procupio Alves; Renato Amaro Zangaro

doi:10.1117/12.474125

13 June 2003 Histological study of hamster buccal mucosa following topical application of DMBA and exposition to low-power 337-nm laser light

Christmas M. V. de Barros Rego, Egberto Munin, Marcela Leal Redigolo, Miguel Castilho Salgado, Hanriete P. de Souza, C. E. D. Colombo, Renata Amadei Nicolau, Leandro Procupio Alves, Renato Amaro Zangaro

Author Affiliations +

Proceedings Volume 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII; (2003) https://doi.org/10.1117/12.474125
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

The aim of the present work is to analyze the histological changes on hamster buccal mucosa caused by the topical use of 7,12-dimethylbenzanthracene (DMBA) and exposition to a 220 µJ/pulse nitrogen laser light (@ 337 nm) at an average power of 2,3 mW. Twenty-one hamsters divided into two experimental groups were treated six times with DMBA. One hamster was kept as control. Group I was composed by ten hamsters and was submitted only to DMBA. Group II, also with ten hamsters, received the same treatment as group I and was exposed to the laser radiation. The time duration of each irradiation section was 10 seconds. All the treatment happened in alternated days. The histological analysis took place twice, after the end of the treatment and after sixty days. Both experimental groups presented dilatation of vessels, thickening of the epithelial tissue and the presence of inflammatory infiltrates. The preliminary results indicates that in group II the number of dilated vessels and its new area are much more significant than in group I.

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Christmas M. V. de Barros Rego, Egberto Munin, Marcela Leal Redigolo, Miguel Castilho Salgado, Hanriete P. de Souza, C. E. D. Colombo, Renata Amadei Nicolau, Leandro Procupio Alves, and Renato Amaro Zangaro "Histological study of hamster buccal mucosa following topical application of DMBA and exposition to low-power 337-nm laser light", Proc. SPIE 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII, (13 June 2003); https://doi.org/10.1117/12.474125

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