Nonlinear matching measure for the analysis of on-off type DNA microarray images

Jong Dae Kim; Misun Park; Jongwon Kim

doi:10.1117/12.478054

18 July 2003 Nonlinear matching measure for the analysis of on-off type DNA microarray images

Jong Dae Kim, Misun Park, Jongwon Kim

Proceedings Volume 4966, Microarrays and Combinatorial Technologies for Biomedical Applications: Design, Fabrication, and Analysis; (2003) https://doi.org/10.1117/12.478054
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

In this paper, we propose a new nonlinear matching measure for automatic analysis of the on-off type DNA microarray images in which the hybridized spots are detected by the template matching method. The targeting spots of HPV DNA chips are designed for genotyping the human papilloma virus(HPV). The proposed measure is obtained by binarythresholding over the whole template region and taking the number of white pixels inside the spotted area. This measure is evaluated in terms of the accuracy of the estimated marker location to show better performance than the normalized covariance.

Citation Download Citation

Jong Dae Kim, Misun Park, and Jongwon Kim "Nonlinear matching measure for the analysis of on-off type DNA microarray images", Proc. SPIE 4966, Microarrays and Combinatorial Technologies for Biomedical Applications: Design, Fabrication, and Analysis, (18 July 2003); https://doi.org/10.1117/12.478054

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