Regional white matter volume and the relation with attentional functioning in survivors of malignant pediatric brain tumors

John O. Glass; Raymond K. Mulhern; Holly A. White; Gina M. Wilkinson; Wilburn E. Reddick

doi:10.1117/12.480395

2 May 2003 Regional white matter volume and the relation with attentional functioning in survivors of malignant pediatric brain tumors

John O. Glass, Raymond K. Mulhern, Holly A. White, Gina M. Wilkinson, Wilburn E. Reddick

Author Affiliations +

Proceedings Volume 5031, Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications; (2003) https://doi.org/10.1117/12.480395
Event: Medical Imaging 2003, 2003, San Diego, California, United States

Abstract

Quantitative assessment of MR examinations in 37 survivors of childhood cancer treated with central nervous system prophylaxis revealed that normal appearing white matter (NAWM) volume is associated with attention-related problems, localized specifically in the right prefrontal region. T1-, T2-, and PD-weighted images were segmented and divided into pre-frontal, frontal, parietal/temporal, and parietal/occipital regions for each hemisphere. These eight regions were analyzed in five slices centered at the level of the basal ganglia. The patient's age at diagnosis and time elapsed from diagnosis were used as covariates in the regressions. Attentional measures showed significant deficiency when compared to age and gender normative values. Total, frontal and/or prefrontal NAWM volumes from the range of slices examined were significantly associated with 5 of the 8 attentional measures. The frontal/prefrontal region of the brain is associated with executive functioning tasks and could potentially be spared as much as possible during therapy planning. The results of the present study further support the contention that NAWM is an important substrate for treatment-induced neurocognitive problems among survivors of malignant brain tumors of childhood.

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John O. Glass, Raymond K. Mulhern, Holly A. White, Gina M. Wilkinson, and Wilburn E. Reddick "Regional white matter volume and the relation with attentional functioning in survivors of malignant pediatric brain tumors", Proc. SPIE 5031, Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications, (2 May 2003); https://doi.org/10.1117/12.480395

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