Fluorescence microscopy studies of a peripheral-benzodiazepine-receptor-targeted molecular probe for brain tumor imaging

Laura Marcu; P. Thomas Vernier; H. Charles Manning; Sarah Salemi; Aimin Li; Cheryl M. Craft; Martin A. Gundersen; Darryl J. Bornhop

doi:10.1117/12.501033

8 October 2003 Fluorescence microscopy studies of a peripheral-benzodiazepine-receptor-targeted molecular probe for brain tumor imaging

Laura Marcu, P. Thomas Vernier, H. Charles Manning, Sarah Salemi, Aimin Li, Cheryl M. Craft, Martin A. Gundersen, Darryl J. Bornhop

Author Affiliations +

Proceedings Volume 5141, Diagnostic Optical Spectroscopy in Biomedicine II; (2003) https://doi.org/10.1117/12.501033
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

This study investigates the potential of a new multi-modal lanthanide chelate complex for specifically targeting brain tumor cells. We report here results from ongoing studies of up-take, sub-cellular localization and binding specificity of this new molecular imaging probe. Fluorescence microscopy investigations in living rat C6 glioma tumor cells demonstrate that the new imaging agent has affinity for glioma cells and binds to mitochondria.

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Laura Marcu, P. Thomas Vernier, H. Charles Manning, Sarah Salemi, Aimin Li, Cheryl M. Craft, Martin A. Gundersen, and Darryl J. Bornhop "Fluorescence microscopy studies of a peripheral-benzodiazepine-receptor-targeted molecular probe for brain tumor imaging", Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); https://doi.org/10.1117/12.501033

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KEYWORDS

Luminescence

Tumors

Brain

Microscopy

Neuroimaging

Lanthanides

Digital image correlation

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