Lifetime fluorescence apparatus for clinical investigations of tissues

Laura Marcu; Qiyin Fang; Thanassis Papaioannou; Javier A. Jo; Russel Vaitha; Kumar Shastry

doi:10.1117/12.501020

8 October 2003 Lifetime fluorescence apparatus for clinical investigations of tissues

Laura Marcu, Qiyin Fang, Thanassis Papaioannou, Javier A. Jo, Russel Vaitha, Kumar Shastry

Proceedings Volume 5141, Diagnostic Optical Spectroscopy in Biomedicine II; (2003) https://doi.org/10.1117/12.501020
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

We report on the design, development, and performance of a versatile and mobile fiber-optic based time-resolved fluorescence apparatus for in-vivo spectroscopy of biological tissues. The apparatus is of modular design which allows for facile interfacing with different pulsed light sources and fiber-optic probes. Main features of the apparatus include: 1) fast acquisition of fluorescence decays with high temporal resolution (0.3 ns) for a broad range of emission wavelengths (300 to 850 nm) and lifetimes (0.3 ns to ms), 2) near real time analysis of fluorescence decays via a Laguerre deconvolution technique, and 3) compatibility with the clinical environment (endoscopic procedures or other intraoperative uses). The apparatus is currently employed for in-vivo studies of diseased tissues (cardiovascular and oncological applications).

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Laura Marcu, Qiyin Fang, Thanassis Papaioannou, Javier A. Jo, Russel Vaitha, and Kumar Shastry "Lifetime fluorescence apparatus for clinical investigations of tissues", Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); https://doi.org/10.1117/12.501020

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KEYWORDS

Luminescence

Tissues

Fiber optics

Time resolved spectroscopy

Deconvolution

In vivo imaging

Fluorescence spectroscopy

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