Demonstration of the true-reflection OCT imaging algorithm on a heterogeneous multilayered structure

Lars Thrane; Michael H. Frosz; Andreas Tycho; Thomas Martini Jorgensen; Harold T. Yura; Peter Eskil Andersen

doi:10.1117/12.529195

1 July 2004 Demonstration of the true-reflection OCT imaging algorithm on a heterogeneous multilayered structure

Lars Thrane, Michael H. Frosz, Andreas Tycho, Thomas Martini Jorgensen, Harold T. Yura, Peter Eskil Andersen

Proceedings Volume 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII; (2004) https://doi.org/10.1117/12.529195
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

A recently developed analytical optical coherence tomography (OCT) model (L. Thrane et al., J. Opt. Soc. Am. A 17, 484 (2000)) allows the extraction of optical scattering parameters therby enabling attenuation compensation in OCT images. By expanding this theoretical model, we have delevoped a new method for extracting optical scattering parameters from multi-layered tissue structures in vivo. To verify this, we have used a Monte Carlo (MC) OCT model as a numerical phantom to simulate the OCT signal for heterogeneous multi-layered tissue. Excellent agreement is obtained between the extracted values for the optical scattering properties of the different layers and the corresponding input reference values of the MC simulation, which demonstrates its feasibility for in vivo applications. This is the first time such a verification has been obtained, which holds promise of expanding the funtional imaging capabilities of OCT.

Citation Download Citation

Lars Thrane, Michael H. Frosz, Andreas Tycho, Thomas Martini Jorgensen, Harold T. Yura, and Peter Eskil Andersen "Demonstration of the true-reflection OCT imaging algorithm on a heterogeneous multilayered structure", Proc. SPIE 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, (1 July 2004); https://doi.org/10.1117/12.529195

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