Time domain fluorescent diffuse optical tomography

Sirithy Lam; Frederic Lesage; Xavier Intes

doi:10.1117/12.593754

9 December 2004 Time domain fluorescent diffuse optical tomography

Sirithy Lam, Frederic Lesage, Xavier Intes

Proceedings Volume 5578, Photonics North 2004: Photonic Applications in Astronomy, Biomedicine, Imaging, Materials Processing, and Education; (2004) https://doi.org/10.1117/12.593754
Event: Photonics North, 2004, Ottawa, Ontario, Canada

Abstract

Light propagation in tissue is known to be favored in the near infrared spectral range. Capitalizing on this fact, new classes of molecular contrast agents are engineered to fluoresce in the NIR. The potential of these new agents is vast as it allows tracking non-invasively and quantitatively specific molecular events in-vivo. However, to monitor the bio-distribution of such compounds in thick tissue proper physical models of light propagation are necessary. To recover 3D concentrations of the compound distribution, it is necessary to perform a model based inverse problem: Diffuse Optical tomography. In this work, we focus on fluorescent diffuse optical tomography expressed within the normalized Born approach. More precisely, we investigate the performances of Fluorescence Molecular Tomography (FMT) in the case of time resolved measurements. The different moments of the time point spread function (TPSF) were analytically derived to construct the forward model. The derivation was performed from the zero order moment to the second moment. This new forward model approach was validated with simulations based on relevant parameters. Enhanced performance of FMT was achieved using these new analytical solutions when compared to the current formulations.

Citation Download Citation

Sirithy Lam, Frederic Lesage, and Xavier Intes "Time domain fluorescent diffuse optical tomography", Proc. SPIE 5578, Photonics North 2004: Photonic Applications in Astronomy, Biomedicine, Imaging, Materials Processing, and Education, (9 December 2004); https://doi.org/10.1117/12.593754

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available