Detect-to-treat: development of analysis of bacilli spores in nasal mucus by surfaced-enhanced Raman spectroscopy

Frank E. Inscore; Alan D. Gift; Stuart Farquharson

doi:10.1117/12.580460

16 December 2004 Detect-to-treat: development of analysis of bacilli spores in nasal mucus by surfaced-enhanced Raman spectroscopy

Frank E. Inscore, Alan D. Gift, Stuart Farquharson

Author Affiliations +

Proceedings Volume 5585, Chemical and Biological Point Sensors for Homeland Defense II; (2004) https://doi.org/10.1117/12.580460
Event: Optics East, 2004, Philadelphia, Pennsylvania, United States

Abstract

As the war on terrorism in Afghanistan and Iraq continue, future attacks both abroad and in the U.S.A. are expected. In an effort to aid civilian and military personnel, we have been investigating the potential of using a surface-enhanced Raman spectroscopy (SERS) sampling device to detect Bacillus anthracis spores in nasal swab samples. Such a device would be extremely beneficial to medical responders and management in assessing the extent of a bioterrorist attack and making detect-to-treat decisions. The disposable sample device consists of a glass capillary filled with a silver-doped sol-gel that is capable of extracting dipicolinic acid (DPA), a chemical signature of Bacilli, and generating SERS spectra. The sampling device and preliminary measurements of DPA extracted from spores and nasal mucus will be presented.

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Frank E. Inscore, Alan D. Gift, and Stuart Farquharson "Detect-to-treat: development of analysis of bacilli spores in nasal mucus by surfaced-enhanced Raman spectroscopy", Proc. SPIE 5585, Chemical and Biological Point Sensors for Homeland Defense II, (16 December 2004); https://doi.org/10.1117/12.580460

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