Glucose quantification in highly scattering media using diffuse reflectance polarization imaging

Yanfang Li; Brent D. Cameron

doi:10.1117/12.571444

7 December 2004 Glucose quantification in highly scattering media using diffuse reflectance polarization imaging

Yanfang Li, Brent D. Cameron

Proceedings Volume 5588, Smart Medical and Biomedical Sensor Technology II; (2004) https://doi.org/10.1117/12.571444
Event: Optics East, 2004, Philadelphia, Pennsylvania, United States

Abstract

Recently, polarization based optical approaches have received considerable interest due to their potential medical applications. Glucose, a chiral molecule, has the ability to rotate the plane of linearly polarized light, commonly referred to as optical activity, as well as affecting the refractive index of the media which is therefore affects the overall scattering coefficient in a given media. The magnitude of each effect is related to the concentration of glucose. Based on these effects, it would be expected that a change in glucose concentration would alter the diffuse reflectance polarization patterns from turbid media. In this study, we investigate how each of these effects is correlated to glucose concentration in a physiological range for highly scattering biological media. Furthermore, it is shown how diffusely polarized imaging when coupled with chemometrics techniques can be used to quantify glucose concentration.

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Yanfang Li and Brent D. Cameron "Glucose quantification in highly scattering media using diffuse reflectance polarization imaging", Proc. SPIE 5588, Smart Medical and Biomedical Sensor Technology II, (7 December 2004); https://doi.org/10.1117/12.571444

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KEYWORDS

Glucose

Polarization

Scattering

Calibration

Diffuse reflectance spectroscopy

Scattering media

Light scattering

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