System design considerations for an x-ray phase-contrast imaging system based on in-line holography

Xizeng Wu; Hong Liu; Aimin Yan

doi:10.1117/12.605350

18 January 2005 System design considerations for an x-ray phase-contrast imaging system based on in-line holography

Xizeng Wu, Hong Liu, Aimin Yan

Proceedings Volume 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II; (2005) https://doi.org/10.1117/12.605350
Event: Photonics Asia, 2004, Beijing, China

Abstract

Since Roentgen discovered x-ray and performed the first x-ray imaging more than 100 years ago, x-ray imaging has always been based on the biological tissue's differences in x-ray attenuation. However, x-ray-tissue interaction causes x-ray phase changes as well, and the tissue’s differences in phase are about one thousand times larger than their differences in x-ray attenuation. We will present the theoretical foundation and design considerations for clinical x-ray phase-contrast imaging systems based on the x-ray in-line holography. Different from the analysis in literature, we proposed a new formalism for in-line phase-contrast imaging to analyze the effects of four clinically important factors on the phase-contrast. These are the body parts attenuation, the spatial coherence of incident x-ray from an x-ray tube, polychromatic x-ray and radiation dose to patients for clinical applications. We will discuss the phase image-reconstruction based on our new theory for the x-ray in-line holography as well. The theory and image reconstruction algorithms presented in this paper can be applied widely to the diagnostic x-ray imaging applications. The phase-contrast imaging system design guidelines based on the new theory will be discussed and its validation by the computer simulations will be demonstrated.

Citation Download Citation

Xizeng Wu, Hong Liu, and Aimin Yan "System design considerations for an x-ray phase-contrast imaging system based on in-line holography", Proc. SPIE 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, (18 January 2005); https://doi.org/10.1117/12.605350

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