Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT

Kirill V. Larin; Rinat O. Esenaliev; Eunha Kim; Sanghoon Oh; Massoud Motamedi; Thomas E. Milner

doi:10.1117/12.590534

13 April 2005 Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT

Kirill V. Larin, Rinat O. Esenaliev, Eunha Kim, Sanghoon Oh, Massoud Motamedi, Thomas E. Milner

Proceedings Volume 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX; (2005) https://doi.org/10.1117/12.590534
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Functional imaging of clear and tissue-simulating phantoms using phase-resolved swept-source spectroscopic OCT (PhS-SSOCT) is described. Superior sensitivity of PhS-SSOCT technique to monitor ultra-small changes in sample refractive index is demonstrated using aqueous solutions of glucose and aqueous suspensions of polystyrene microspheres and glucose. Glucose-induced changes in the phase are found to be 0.039 rad/mM and 0.037 rad/mM in the 200 μm-thick cell for clear and turbid media, respectively, that is in good agreement with our previous data obtained using differential-phase time-domain OCT. Obtained results suggest that PhS-SSOCT has a potential for noninvasive, depth-resolved, real-time quantitative monitoring of concentrations of glucose and other analytes with high accuracy.

Citation Download Citation

Kirill V. Larin, Rinat O. Esenaliev, Eunha Kim, Sanghoon Oh, Massoud Motamedi, and Thomas E. Milner "Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT", Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, (13 April 2005); https://doi.org/10.1117/12.590534

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