Preliminary study of mechanism of non-invasive blood glucose measurement based on near-infrared diffuse reflectance spectroscopy

Wenliang Chen; Rong Liu; Yunhan Luo; Yonghui Han; Kexin Xu

doi:10.1117/12.589597

29 March 2005 Preliminary study of mechanism of non-invasive blood glucose measurement based on near-infrared diffuse reflectance spectroscopy

Wenliang Chen, Rong Liu, Yunhan Luo, Yonghui Han, Kexin Xu

Author Affiliations +

Proceedings Volume 5696, Complex Dynamics and Fluctuations in Biomedical Photonics II; (2005) https://doi.org/10.1117/12.589597
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Non-invasive glucose measurement by near-infrared spectroscopy is mainly based on the absorption of glucose. However, for non-invasive blood glucose measurement, the diffuse reflectance spectra are influenced not only by the absorption coefficient, but also by the scattering coefficient, anisotropy factor, and refractive index, which are normally nonlinear with the glucose concentrations. Furthermore, the variations of spectra depend on the relative changing direction of the absorption coefficient and scattering coefficient. In this paper, using the simulated samples of human tissues with different glucose concentrations in different conditions, we discussed the rules of how the glucose concentrations affected the absorption coefficient and scattering coefficient, respectively. The relations between the diffuse reflectance spectra and the absorption coefficient, as well as and the scattering coefficient were also investigated. Thus, we confirmed which of the optical parameters and measurement conditions would affect the diffuse reflectance spectra significantly. Based on the above results, proper methods could be selected to measure blood glucose concentration non-invasively according to different conditions, then the information of glucose absorption would be extracted more effectively, and higher measurement precision would be expected.

Citation Download Citation

Wenliang Chen, Rong Liu, Yunhan Luo, Yonghui Han, and Kexin Xu "Preliminary study of mechanism of non-invasive blood glucose measurement based on near-infrared diffuse reflectance spectroscopy", Proc. SPIE 5696, Complex Dynamics and Fluctuations in Biomedical Photonics II, (29 March 2005); https://doi.org/10.1117/12.589597

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