Evaluation of contrast-enhanced power Doppler imaging for measuring blood flow

Sara Ansaloni; Peter H. Arger M.D.; Ted W. Cary; Chandra M. Sehgal

doi:10.1117/12.595382

12 April 2005 Evaluation of contrast-enhanced power Doppler imaging for measuring blood flow

Sara Ansaloni, Peter H. Arger M.D., Ted W. Cary, Chandra M. Sehgal

Proceedings Volume 5750, Medical Imaging 2005: Ultrasonic Imaging and Signal Processing; (2005) https://doi.org/10.1117/12.595382
Event: Medical Imaging, 2005, San Diego, California, United States

Abstract

Power Doppler ultrasound enhanced by microbubble contrast agent has been used to image tissue vascularity and blood flow for the assessment of antivascular therapies. We have proposed a multigating technique that measures bubble concentration as a function of ultrasound exposure for deriving tumor blood flow and vascularity.1 Techniques using ultrasound contrast agent are known to be sensitive to the choice of imaging parameters like mechanical index and tissue attenuation. In this paper, the roles of mechanical index (MI) and tissue attenuation were evaluated experimentally in a rubber tubing flow phantom connected to a mixing chamber and a variable speed pump. The contrast was injected in the mixing chamber and the flow rate was measured using power Doppler imaging. The measurements were repeated at different MIs (0.1 to 1.3), and at different levels of attenuation, obtained with solutions of glycerol-water (10-20%). True flow was measured by collecting liquid flowing out of the phantom over a fixed duration. At low MI (<0.5), the grayscale and Doppler signal were weak, making these images unsuitable for analysis. At higher MI (> 0.8), there was a well-defined enhancement by contrast agent resulting in reproducible flow measurements at variable MIs. A balance between the number of bubbles destroyed and the echo they generate must be achieved for optimal imaging. The increased attenuation of ultrasound by the overlying medium did not influence the flow measurements.

Citation Download Citation

Sara Ansaloni, Peter H. Arger M.D., Ted W. Cary, and Chandra M. Sehgal "Evaluation of contrast-enhanced power Doppler imaging for measuring blood flow", Proc. SPIE 5750, Medical Imaging 2005: Ultrasonic Imaging and Signal Processing, (12 April 2005); https://doi.org/10.1117/12.595382

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
10 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Signal attenuation

Doppler effect

Image enhancement

Ultrasonography

Blood circulation

Image acquisition

Tissues

Show All Keywords

Keywords/Phrases

Search In:

Publication Years