High-performance broad-band spectroscopy for breast cancer risk assessment

Olga Pawluczyk; Kristina Blackmore; Samantha Dick; Lothar Lilge

doi:10.1117/12.629075

13 October 2005 High-performance broad-band spectroscopy for breast cancer risk assessment

Olga Pawluczyk, Kristina Blackmore, Samantha Dick, Lothar Lilge

Proceedings Volume 5969, Photonic Applications in Biosensing and Imaging; 59691M (2005) https://doi.org/10.1117/12.629075
Event: Photonics North, 2005, Toronto, Canada

Abstract

Medical diagnostics and screening are becoming increasingly demanding applications for spectroscopy. Although for many years the demand was satisfied with traditional spectrometers, analysis of complex biological samples has created a need for instruments capable of detecting small differences between samples. One such application is the measurement of absorbance of broad spectrum illumination by breast tissue, in order to quantify the breast tissue density. Studies have shown that breast cancer risk is closely associated with the measurement of radiographic breast density measurement. Using signal attenuation in transillumination spectroscopy in the 550-1100nm spectral range to measure breast density, has the potential to reduce the frequency of ionizing radiation, or making the test accessible to younger women; lower the cost and make the procedure more comfortable for the patient. In order to determine breast density, small spectral variances over a total attenuation of up to 8 OD have to be detected with the spectrophotometer. For this, a high performance system has been developed. The system uses Volume Phase Holographic (VPH) transmission grating, a 2D detector array for simultaneous registration of the whole spectrum with high signal to noise ratio, dedicated optical system specifically optimized for spectroscopic applications and many other improvements. The signal to noise ratio exceeding 50,000 for a single data acquisition eliminates the need for nitrogen cooled detectors and provides sufficient information to predict breast tissue density. Current studies employing transillumination breast spectroscopy (TIBS) relating to breast cancer risk assessment and monitoring are described.

Citation Download Citation

Olga Pawluczyk, Kristina Blackmore, Samantha Dick, and Lothar Lilge "High-performance broad-band spectroscopy for breast cancer risk assessment", Proc. SPIE 5969, Photonic Applications in Biosensing and Imaging, 59691M (13 October 2005); https://doi.org/10.1117/12.629075

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