Novel sensor for ultrasensitive and single-molecule detection

K. Linga; E. Godik; J. Krutov; V. B. Zaitsev; V. E. Shubin; D. A. Shushakov; S. L. Vinogradov

doi:10.1117/12.647150

27 February 2006 Novel sensor for ultrasensitive and single-molecule detection

K. Linga, E. Godik, J. Krutov, V. B. Zaitsev, V. E. Shubin, D. A. Shushakov, S. L. Vinogradov

Proceedings Volume 6092, Ultrasensitive and Single-Molecule Detection Technologies; 60920X (2006) https://doi.org/10.1117/12.647150
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

The detection and identification of single molecules represent one of the ultimate goals of analytical chemistry. We have designed, developed and tested a new family of photodetectors with Internal Discrete Amplification (IDA) mechanism. These photodetectors can operate in linear (analog) detection mode with gain-bandwidth product up to 5.10¹⁴ and one- or few-photon sensitivity, as well as in the photon counting mode with count rates up to 10⁸ cps. Their key performance characteristics exceed those of photomultiplier tube (PMT) and avalanche photodiode (APD) devices. The measured parameters of the detectors are: gain > 10⁵, excess noise factor as low as 1.02, maximum count rate > 10⁸ counts/s, and rise/fall time < 300 ps. The new family of the photo detectors may become an ideal solution for the problems of ultrasensitive and single-molecule detection by fluorescence spectroscopy and other optical methods.

Citation Download Citation

K. Linga, E. Godik, J. Krutov, V. B. Zaitsev, V. E. Shubin, D. A. Shushakov, and S. L. Vinogradov "Novel sensor for ultrasensitive and single-molecule detection", Proc. SPIE 6092, Ultrasensitive and Single-Molecule Detection Technologies, 60920X (27 February 2006); https://doi.org/10.1117/12.647150

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