Probing molecules by surface-enhanced Raman spectroscopy

M. Caterina Netti; M. E. Zoorob; Martin D. B. Charlton; Peter Ayliffe; Sven Mahnkopf; Paul Stopford; K. Todd; John R. Lincoln; Nicolas M. B. Perney; Jeremy J. Baumberg

doi:10.1117/12.646368

27 February 2006 Probing molecules by surface-enhanced Raman spectroscopy

M. Caterina Netti, M. E. Zoorob, Martin D. B. Charlton, Peter Ayliffe, Sven Mahnkopf, Paul Stopford, K. Todd, John R. Lincoln, Nicolas M. B. Perney, Jeremy J. Baumberg

Author Affiliations +

Proceedings Volume 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry; 60930F (2006) https://doi.org/10.1117/12.646368
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

A new class of Surface-Enhanced Raman Scattering (SERS) substrates have been engineered by exploiting both Photonic Crystal (PC) and semiconductor technologies. Gold coated inverted pyramids nanotextured substrates allow reproducibility <10% and enhancement factors > 10⁶ over large areas. Modelling and optical characterization of the engineered structures is demonstrated. Examples of applications to amino acids and illicit drug detection are given. Concentrations as low as ppm-ppb (mg/mL to ng/mL) have been measured depending on the adsorbed analytes. Information on structure and conformation of the molecule is inferred due to the richer nature of SERS spectra.

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M. Caterina Netti, M. E. Zoorob, Martin D. B. Charlton, Peter Ayliffe, Sven Mahnkopf, Paul Stopford, K. Todd, John R. Lincoln, Nicolas M. B. Perney, and Jeremy J. Baumberg "Probing molecules by surface-enhanced Raman spectroscopy", Proc. SPIE 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry, 60930F (27 February 2006); https://doi.org/10.1117/12.646368

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