Two-photon triggered drug delivery system: a new way to prevent posterior capsule opacification

H.-C. Kim; S. Härtner; N. Hampp

doi:10.1117/12.646098

7 March 2006 Two-photon triggered drug delivery system: a new way to prevent posterior capsule opacification

H.-C. Kim, S. Härtner, N. Hampp

Proceedings Volume 6138, Ophthalmic Technologies XVI; 61380S (2006) https://doi.org/10.1117/12.646098
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

One of the major complications of cataract surgery is posterior capsule opacification caused by proliferation and migration of residual lens epithelial cells into the visual axis. In this study we present a novel approach to treat posterior capsule opacification in a non-invasive manner. A polymer-drug conjugate has been developed which is suitable for manufacturing functional intraocular lenses equipped with a drug delivery system. The therapeutic molecules, 5-fluorouracil, were attached through a photolabile linkage to the acrylic polymer backbone of the intraocular lens material. The controlled release of 5-fluorouracil is accomplished by two-photon induced cleavage of the linkage which is stable in ordinary conditions. The properties of the therapeutic system are characterized and the function is demonstrated in in vitro tests. The utilization of two-photon-absorption processes in drug delivery may provide a powerful tool to prevent posterior capsule opacification.

Citation Download Citation

H.-C. Kim, S. Härtner, and N. Hampp "Two-photon triggered drug delivery system: a new way to prevent posterior capsule opacification", Proc. SPIE 6138, Ophthalmic Technologies XVI, 61380S (7 March 2006); https://doi.org/10.1117/12.646098

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available