Spectral studies of polycyclic aromatic hydrocarbon interaction with human blood plasma

A. G. Melnikov; A. B. Pravdin; V. I. Kochubey; G. V. Melnikov

doi:10.1117/12.697351

24 July 2006 Spectral studies of polycyclic aromatic hydrocarbon interaction with human blood plasma

A. G. Melnikov, A. B. Pravdin, V. I. Kochubey, G. V. Melnikov

Proceedings Volume 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII; 61631H (2006) https://doi.org/10.1117/12.697351
Event: Saratov Fall Meeting 2005, 2005, Saratov, Russian Federation

Abstract

Analysis of fluorescence spectra of polycyclic aromatic hydrocarbons in human blood plasma and human serum albumin solution allowed one to conclude that pyrene and also anthracene are predominantly distributed in the hydrophobic micro-phase of blood plasma proteins. In the solution of human blood plasma containing pyrene the nonmonotonic dependence of both the intensity of pyrene fluorescence and the index of polarity on the concentration of sodium dodecylsulfate added was observed. This should be connected with the reconstruction of the structure of protein globule under the surfactant action and cannot be explained only by the solubilization of pyrene in sodium dodecylsulfate micelles.

Citation Download Citation

A. G. Melnikov, A. B. Pravdin, V. I. Kochubey, and G. V. Melnikov "Spectral studies of polycyclic aromatic hydrocarbon interaction with human blood plasma", Proc. SPIE 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, 61631H (24 July 2006); https://doi.org/10.1117/12.697351

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