Mechanical extension implants for short-bowel syndrome

Jonathan Luntz; Diann Brei; Daniel Teitelbaum M.D.; Ariel Spencer M.D.

doi:10.1117/12.659112

5 April 2006 Mechanical extension implants for short-bowel syndrome

Jonathan Luntz, Diann Brei, Daniel Teitelbaum M.D., Ariel Spencer M.D.

Proceedings Volume 6173, Smart Structures and Materials 2006: Smart Structures and Integrated Systems; 617309 (2006) https://doi.org/10.1117/12.659112
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2006, San Diego, California, United States

Abstract

Short-bowel syndrome (SBS) is a rare, potentially lethal medical condition where the small intestine is far shorter than required for proper nutrient absorption. Current treatment, including nutritional, hormone-based, and surgical modification, have limited success resulting in 30% to 50% mortality rates. Recent advances in mechanotransduction, stressing the bowel to induce growth, show great promise; but for successful clinical use, more sophisticated devices that can be implanted are required. This paper presents two novel devices that are capable of the long-term gentle stressing. A prototype of each device was designed to fit inside a short section of bowel and slowly extend, allowing the bowel section to grow approximately double its initial length. The first device achieves this through a dual concentric hydraulic piston that generated almost 2-fold growth of a pig small intestine. For a fully implantable extender, a second device was developed based upon a shape memory alloy actuated linear ratchet. The proof-of-concept prototype demonstrated significant force generation and almost double extension when tested on the benchtop and inside an ex-vivo section of pig bowel. This work provides the first steps in the development of an implantable extender for treatment of SBS.

Citation Download Citation

Jonathan Luntz, Diann Brei, Daniel Teitelbaum M.D., and Ariel Spencer M.D. "Mechanical extension implants for short-bowel syndrome", Proc. SPIE 6173, Smart Structures and Materials 2006: Smart Structures and Integrated Systems, 617309 (5 April 2006); https://doi.org/10.1117/12.659112

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