Submicro foaming in biopolymers by UV pulsed laser irradiation

Mohamed Oujja; Esther Rebollar; Solenne Gaspard; Concepción Abrusci; Fernando Catalina; Sylvain Lazare; Marta Castillejo

doi:10.1117/12.668958

7 June 2006 Submicro foaming in biopolymers by UV pulsed laser irradiation

Mohamed Oujja, Esther Rebollar, Solenne Gaspard, Concepción Abrusci, Fernando Catalina, Sylvain Lazare, Marta Castillejo

Author Affiliations +

Proceedings Volume 6261, High-Power Laser Ablation VI; 62611L (2006) https://doi.org/10.1117/12.668958
Event: High-Power Laser Ablation 2006, 2006, Taos, NM, United States

Abstract

Microstructuring of polymers and biopolymers is of application in medical technology and biotechnology. Using different fabrication techniques three-dimensionally shaped and micro structured constructs can be developed for drug release and tissue engineering. As an alternative method, laser microstructuring offers a series of advantages including high resolution capability, low heat deposition in the substrate and high level of flexibility. In this work we present evidence of laser microfoam formation in collagen and gelatine by nanosecond pulsed laser irradiation in the UV at 248 and 266 nm. Irradiation at 355 nm produces melting followed by resolidification of the substrate, whereas irradiation at 532 and 1064 nm induces the formation of craters of irregular contours. Single pulse irradiation of a collagen film with an homogenized KrF microbeam yields a 20 μm thick expanded layer, which displays the interesting features of a nanofibrous 3-dimensional network with open cells. In gelatine, irradiation at 248 and 266 nm produces similar morphological modifications. The effect of the structural properties of the substrate on the laser induced microfoam is studied by comparing gelatines differing in gel strength (Bloom values 225 and 75) and in crosslinking degree. While results are discussed on the basis of thermal and photomechanical mechanisms and of the role played by the water content of the substrates, it is thought that such structures could have a biomimic function in future 3D cell culture devices for research.

Citation Download Citation

Mohamed Oujja, Esther Rebollar, Solenne Gaspard, Concepción Abrusci, Fernando Catalina, Sylvain Lazare, and Marta Castillejo "Submicro foaming in biopolymers by UV pulsed laser irradiation", Proc. SPIE 6261, High-Power Laser Ablation VI, 62611L (7 June 2006); https://doi.org/10.1117/12.668958

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