Real time on-line intracavity detection of chemicals in solution

Untzizu Elejalde; John M. Girkin

doi:10.1117/12.696558

10 February 2007 Real time on-line intracavity detection of chemicals in solution

Untzizu Elejalde, John M. Girkin

Proceedings Volume 6444, Ultrasensitive and Single-Molecule Detection Technologies II; 644407 (2007) https://doi.org/10.1117/12.696558
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

We have investigated the application of narrow-band intracavity spectroscopy for high throughput characterization and detection of reaction products in-situ. An external cavity diode laser (ECDL), tunable from 810-890 nm, is used to measure varying concentrations of a range of compounds in solution. A linear calibration curve for parts per billion (ppb) concentrations corresponding to 17 nM has been achieved, levels not detectable with UV/VIS spectrometers. By replacing the grating with a high reflective mirror, parts per trillion (ppt) concentration detection was also achieved corresponding to 340 pM. We believe that this technique provides a method for fast and safe measurements of reactions in real time and has potential applications in the pharmaceutical and chemical industry as well as for integrated bio-diagnostics lab-on-a-chip devices.

Citation Download Citation

Untzizu Elejalde and John M. Girkin "Real time on-line intracavity detection of chemicals in solution", Proc. SPIE 6444, Ultrasensitive and Single-Molecule Detection Technologies II, 644407 (10 February 2007); https://doi.org/10.1117/12.696558

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