Enhancement of taxol-induced apoptosis by inhibition of NF-&#954;B with ursorlic acid

Yunlong Li; Da Xing

doi:10.1117/12.741583

1 May 2007 Enhancement of taxol-induced apoptosis by inhibition of NF-κB with ursorlic acid

Yunlong Li, Da Xing

Proceedings Volume 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine; 65341H (2007) https://doi.org/10.1117/12.741583
Event: Fifth International Conference on Photonics and Imaging in Biology and Medicine, 2006, Wuhan, China

Abstract

Taxol is known to inhibit cell growth and triggers significant apoptosis in various cancer cells, and activation of proliferation factor NF-κB during Taxol-induced apoptosis is regarded as a main reason resulting in tumor cells resistance to Taxol. It has been found that ursorlic acid can inhibit the activation of NF-κB. In order to study whether ursorlic acid can enhance the Taxol-induced apoptosis, we use fluorescence resonance energy transfer (FRET) technique and probe SCAT3 to compare the difference of caspase-3 activation between Taxol alone and Taxol combined ursorlic acid. With laser scanning confocal microscopy, we find that ursorlic acid, a nontoxic food component, sensitizes ASTC-a-1 cells more efficiently to Taxol-induced apoptosis by advanced activation of caspase 3. The result also suggests that there would be a synergistic effect between Taxol and ursorlic acid, and the more detailed mechanism of synergistic effect needs to be clarified further, such as the correlations among NF-κB, Akt, caspase 8, which leads to the advanced activation of caspase 3 during combined treatment of Taxol and ursorlic acid. Moreover, this may be a new way to improve Taxol-dependent tumor therapy.

Citation Download Citation

Yunlong Li and Da Xing "Enhancement of taxol-induced apoptosis by inhibition of NF-κB with ursorlic acid", Proc. SPIE 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine, 65341H (1 May 2007); https://doi.org/10.1117/12.741583

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