Imaging of gold nanoshell clearance in animal brains in vivo by improved-simultaneous-iterative-based photoacoustic tomography

Liangzhong Xiang; Da Xing; Huaimin Gu; Diwu Yang; Sihua Yang; Lvming Zeng

doi:10.1117/12.741448

1 May 2007 Imaging of gold nanoshell clearance in animal brains in vivo by improved-simultaneous-iterative-based photoacoustic tomography

Liangzhong Xiang, Da Xing, Huaimin Gu, Diwu Yang, Sihua Yang, Lvming Zeng

Author Affiliations +

Proceedings Volume 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine; 653430 (2007) https://doi.org/10.1117/12.741448
Event: Fifth International Conference on Photonics and Imaging in Biology and Medicine, 2006, Wuhan, China

Abstract

The high contrast and high resolution photoacoustic tomography was used to image the gold nanoshell clearance in rat brain in vivo. With our current imaging system, the acquisition of photoacoustic signals is realized through a circular scan of a single-element transducer. Therefore, the data acquisition is slow. In this case, an improved simultaneous iterative reconstruction algorithm was developed to reduce the acquisition time by using limited data in the experiments. This algorithm is based on the least square principle; it can be used to reconstruct high quality images from the limited data containing much noise. Furthermore, it is always convergent. So it can improve the imaging quality comparison with conventional filter back-projection algorithm (FBP) and algebraic reconstruction algorithm (ART). Here we accurately mapped rat brain structures with gold nanoshell contrast agents. We also imaged the clearance of gold nanoshell in the rat brain. It provides an accurate non-invasive monitoring method for fluid pathways in biological tissues, which makes photoacoustic tomography as a powerful method for imaging pathologic tumor vessels, delineating neovascularization, and studying global and regional hemodynamic activities in the brain.

Citation Download Citation

Liangzhong Xiang, Da Xing, Huaimin Gu, Diwu Yang, Sihua Yang, and Lvming Zeng "Imaging of gold nanoshell clearance in animal brains in vivo by improved-simultaneous-iterative-based photoacoustic tomography", Proc. SPIE 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine, 653430 (1 May 2007); https://doi.org/10.1117/12.741448

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