The sensitivity to collagen may be useful for diagnostic purposes in mammography, as collagen seems to be involved in
the development of breast cancer. Moreover, collagen content is expected to be related to breast density (i.e. breast
parenchymal pattern) and its quantification could allow the classification of breast type. Thus we have measured the
absorption properties of collagen from 610 to 1040 nm. Absorption spectra of breast from healthy volunteers were then
interpreted adding collagen to the other absorbers previously considered (i.e. oxy- and deoxyhemoglobin, water, and
lipids). A significant amount of collagen, depending on breast type, is estimated to be present and seems to correlate with
breast type. Moreover, adding collagen to the fitting procedure affects remarkably the estimated values of blood content
and oxygenation. We have also upgraded our time-resolved multi-wavelength optical mammograph, adding a long
wavelength (1060 nm) to improve the spectral information and, in particular, the sensitivity to collagen. Breast
measurements on volunteers have recently started.
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