Optical tomographic imaging of activation of the infant auditory cortex using perturbation Monte Carlo with anatomical a priori information

Juha Heiskala; Kalle Kotilahti; Lauri Lipiäinen; Petri Hiltunen; P. Ellen Grant M.D.; Ilkka Nissilä

doi:10.1117/12.728276

12 July 2007 Optical tomographic imaging of activation of the infant auditory cortex using perturbation Monte Carlo with anatomical a priori information

Juha Heiskala, Kalle Kotilahti, Lauri Lipiäinen, Petri Hiltunen, P. Ellen Grant M.D., Ilkka Nissilä

Author Affiliations +

Proceedings Volume 6629, Diffuse Optical Imaging of Tissue; 66290T (2007) https://doi.org/10.1117/12.728276
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

We have developed a perturbation Monte Carlo method for calculating forward and inverse solutions to the optical tomography imaging problem in the presence of anatomical a priori information. The method uses frequency domain data. In the present work, we consider the problem of imaging hemodynamic changes due to brain activation in the infant brain. We test finite element method and Monte Carlo based implementations using a homogeneous model with the exterior of the domain warped to match digitized points on the skin. With the perturbation Monte Carlo model, we also test a heterogeneous model based on anatomical a priori information derived from a previously recorded infant T1 magnetic resonance (MR) image. Our simulations show that the anatomical information improves the accuracy of reconstructions quite significantly even if the anatomical MR images are based on another infant. This suggests that significant benefits can be obtained by the use of generic infant brain atlas information in near-infrared spectroscopy and optical tomography studies.

Citation Download Citation

Juha Heiskala, Kalle Kotilahti, Lauri Lipiäinen, Petri Hiltunen, P. Ellen Grant M.D., and Ilkka Nissilä "Optical tomographic imaging of activation of the infant auditory cortex using perturbation Monte Carlo with anatomical a priori information", Proc. SPIE 6629, Diffuse Optical Imaging of Tissue, 66290T (12 July 2007); https://doi.org/10.1117/12.728276

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available