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Nanotechnology applications for food safety and biosecurity, especially development of nanoscale sensors for foodborne
pathogen measurement are emerging. A novel bio-functional nanosensor for Salmonella detection was developed using
hetero-nanorods. The silica nanorods were fabricated by glancing angle deposition method and the gold was sputtered
onto the silica nanorods. Alexa488-succinimide dye was immobilized onto the annealed Si nanorods via the attachment
between dye ester and primary amine group supplied by the
3-Aminopropyltriethoxysilane. The anti-Salmonella was
conjugated to gold via Dithiobis[succinimidylpropionate]
self-assembly monolayer. Due to the high aspect ratio nature
of the Si nanorods, hundreds or thousands of dye molecules attached to the Si nanorods produced enhanced fluorescence
signal. These biologically functionalized nanorods can be used to detect Salmonella with fluorescent microscopic
imaging. This new nanoscale biosensor will be able to detect other foodborne pathogenic bacteria for food safety and
security applications.
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Bosoon Park, Junxue Fu, Yiping Zhao, Gregory R. Siragusa, Yong-Jin Cho, Kurt C. Lawrence, William R. Windham, "Bio-functional Au/Si nanorods for pathogen detection," Proc. SPIE 6769, Nanosensing: Materials, Devices, and Systems III, 67690O (25 September 2007); https://doi.org/10.1117/12.736486