In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers

Desmond C. Adler; Yu Chen; Robert Huber; Joseph Schmitt; James Connolly; James G. Fujimoto

doi:10.1117/12.761850

5 March 2008 In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers

Desmond C. Adler, Yu Chen, Robert Huber, Joseph Schmitt, James Connolly, James G. Fujimoto

Author Affiliations +

Proceedings Volume 6847, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII; 684708 (2008) https://doi.org/10.1117/12.761850
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

We report an endoscopic optical coherence tomography (OCT) system based on a Fourier Domain Mode Locked (FDML) laser, a novel data acquisition (DAQ) system with optical frequency clocking, and a high-speed spiralscanning fiber probe. The system is capable of acquiring three-dimensional (3D) in vivo datasets at 100,000 axial lines/s and 50 frames/s, enabled by the high sweep rates of the FDML laser and the efficient data processing of the DAQ system. This high imaging rate allows densely-sampled 3D datasets to be acquired, giving a resolvable feature size of 9 &mgr;m x 20 &mgr;m x 7 &mgr;m (transverse x longitudinal x axial, XYZ). In vivo 3D endomicroscopy is demonstrated in the rabbit colon, where individual colonic crypts are clearly visualized and measured. With further improvements in DAQ technology, the imaging speed will be scalable to the hundreds of thousands of axial lines/s supported by FDML lasers.

Citation Download Citation

Desmond C. Adler, Yu Chen, Robert Huber, Joseph Schmitt, James Connolly, and James G. Fujimoto "In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers", Proc. SPIE 6847, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII, 684708 (5 March 2008); https://doi.org/10.1117/12.761850

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available