The relationship of QD composition and conjugate to cellular uptake and toxicity

Jay L. Nadeau; Samuel J. Clarke; Anil Kumar Suresh; Rafael A. Khatchadourian; Eve-Marie Dumas

doi:10.1117/12.762333

22 February 2008 The relationship of QD composition and conjugate to cellular uptake and toxicity

Jay L. Nadeau, Samuel J. Clarke, Anil Kumar Suresh, Rafael A. Khatchadourian, Eve-Marie Dumas

Proceedings Volume 6866, Colloidal Quantum Dots for Biomedical Applications III; 68660J (2008) https://doi.org/10.1117/12.762333
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

In this work, we demonstrate the application of quantum dots (QDs) to several biologically relevant applications. QDs are synthesized by biological and organometallic routes and the relative merits of these methods are identified. Our results indicate that QDs can be functionalized and specifically targeted to both mammalian and bacterial cells. In the case of mammalian cells, they can be targeted to an engineered sodium channel for the purpose of sensing. In both mammalian and bacterial cells, the interaction with bioconjugated QDs can lead to phototoxicity due to the generation of reactive oxygen species (ROS).

Citation Download Citation

Jay L. Nadeau, Samuel J. Clarke, Anil Kumar Suresh, Rafael A. Khatchadourian, and Eve-Marie Dumas "The relationship of QD composition and conjugate to cellular uptake and toxicity", Proc. SPIE 6866, Colloidal Quantum Dots for Biomedical Applications III, 68660J (22 February 2008); https://doi.org/10.1117/12.762333

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