Modeling of epithelia transport phenomena related with the acetowhitening optical changes: potential for the in vivo diagnosis of cervical neoplasia

George Papoutsoglou; Antonis Potirakis; Costas Balas

doi:10.1117/12.781501

8 May 2008 Modeling of epithelia transport phenomena related with the acetowhitening optical changes: potential for the in vivo diagnosis of cervical neoplasia

George Papoutsoglou, Antonis Potirakis, Costas Balas

Author Affiliations +

Proceedings Volume 6991, Biophotonics: Photonic Solutions for Better Health Care; 69912C (2008) https://doi.org/10.1117/12.781501
Event: SPIE Photonics Europe, 2008, Strasbourg, France

Abstract

A molecular imaging method employing acetic acid dilute solution as a biomarker of cervical neoplasia is described and the interpretation of the biophysical processes involved determining the in-vivo measured dynamic scattering characteristics is presented. A compartmental model of the epithelium has been developed for predicting the epithelial transport phenomena that are expected to be correlated with the dynamic characteristics of the backscattered light. Model predictions have been compared and confirmed by experimental data obtained from patients with cervical neoplasia of different grade, with the aid of specially developed imaging system. Results revealed that the dynamic scattering characteristics and both structural and functional alterations are largely determined by the intracellular proton concentration kinetics. This highlights the potential of the developed imaging method and technology for the non-invasive diagnosis, guided therapeutics and screening of cervical neoplasia.

Citation Download Citation

George Papoutsoglou, Antonis Potirakis, and Costas Balas "Modeling of epithelia transport phenomena related with the acetowhitening optical changes: potential for the in vivo diagnosis of cervical neoplasia", Proc. SPIE 6991, Biophotonics: Photonic Solutions for Better Health Care, 69912C (8 May 2008); https://doi.org/10.1117/12.781501

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