Experimental results of antigliadin antibodies detection using long period fiber grating

J. M. Corres; I. R. Matias; J. Goicoechea; F. J. Arregui; D. Viegas; F. M. Araújo; J. L. Santos

doi:10.1117/12.786076

16 May 2008 Experimental results of antigliadin antibodies detection using long period fiber grating

J. M. Corres, I. R. Matias, J. Goicoechea, F. J. Arregui, D. Viegas, F. M. Araújo, J. L. Santos

Proceedings Volume 7004, 19th International Conference on Optical Fibre Sensors; 700442 (2008) https://doi.org/10.1117/12.786076
Event: 19th International Conference on Optical Fibre Sensors, 2008, Perth, WA, Australia

Abstract

In this work a new nano-biofilm is proposed for the detection of celiac disease (CD). A long-period fiber grating (LPFG) is used as a transducer and the surface of the fiber is coated with a precursor layer of SiO₂-nanospheres using the electrostatic self-assembly technique (ESA). This layer has been designed in order to create a substrate of high porosity where the gliadins could be deposited. Under the presence of specific antibodies antigliadin antibodies (AGA) the refractive index of the overlay changes giving a detectable shift in the resonance wavelength of the LPFG. Concentrations as low as 5 ppm were detected.

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J. M. Corres, I. R. Matias, J. Goicoechea, F. J. Arregui, D. Viegas, F. M. Araújo, and J. L. Santos "Experimental results of antigliadin antibodies detection using long period fiber grating", Proc. SPIE 7004, 19th International Conference on Optical Fibre Sensors, 700442 (16 May 2008); https://doi.org/10.1117/12.786076

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