Application of optical trapping for cavitation studies

P. A. Prentice; P. A. Campbell

doi:10.1117/12.794192

22 September 2008 Application of optical trapping for cavitation studies

P. A. Prentice, P. A. Campbell

Proceedings Volume 7038, Optical Trapping and Optical Micromanipulation V; 70381N (2008) https://doi.org/10.1117/12.794192
Event: NanoScience + Engineering, 2008, San Diego, California, United States

Abstract

This study has observed microscopic level cavitation processes in shelled second generation ultrasound contrast agent microbubbles. The spatial and temporal resolutions required for this undertaking have been achieved via a unique hybridisation of optical trapping with ultra high speed microphotography. Upon insonation with ultrasound in the region of 0.5-4MPa, microjets were observed to develop within, and subsequently issue from, cavitating bubbles. Jet impact into target substrates, including monolayers of biological cells, was observed. These observations provide direct evidence for the involvement of microjetting events during ultrasound exposure on live cells, a process that may have future potential as a novel non-invasive route to drug- and gene-based therapies.

Citation Download Citation

P. A. Prentice and P. A. Campbell "Application of optical trapping for cavitation studies", Proc. SPIE 7038, Optical Trapping and Optical Micromanipulation V, 70381N (22 September 2008); https://doi.org/10.1117/12.794192

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