Flow of blood-saline mixtures studied by time-domain optical coherence tomography

Dan P. Popescu; Michael G. Sowa

doi:10.1117/12.808041

20 February 2009 Flow of blood-saline mixtures studied by time-domain optical coherence tomography

Dan P. Popescu, Michael G. Sowa

Proceedings Volume 7186, Optical Diagnostics and Sensing IX; 718607 (2009) https://doi.org/10.1117/12.808041
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

In-vitro analysis of flowing blood-saline mixtures is performed by time-domain optical coherence tomography imaging. The mixtures contain blood in concentrations ranging from 100% to 20%. For each image, a corresponding compounded profile is obtained by adding one thousand adjacent A-scans. The compounded profiles are used for characterizing the optical coherence tomography signal as it propagates within the studied blood-saline mixtures. The results obtained point toward the possibility of acquiring intra-vascular images of arterial tissue that is located behind slabs of flowing blood-saline. A threshold in the propagation distance beyond which the recorded signal becomes dominated by its multiple scattered components is established along the compounded profiles. The threshold location, at a depth of ~0.6 mm, is independent of blood concentration. Further investigation of the compounded profiles reveals that the region extending to a maximum depth of about 200 μm from the point where the probing beam enters blood-saline mixtures could reveal information about the flow regime. This opens the possibility of another application for time-domain optical coherence tomography in intravascular imaging: assessing the flow regime, i.e. laminar or turbulent.

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Dan P. Popescu and Michael G. Sowa "Flow of blood-saline mixtures studied by time-domain optical coherence tomography", Proc. SPIE 7186, Optical Diagnostics and Sensing IX, 718607 (20 February 2009); https://doi.org/10.1117/12.808041

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KEYWORDS

Optical coherence tomography

Blood

Signal detection

Signal attenuation

Light scattering

Scattering

Speckle

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