Characterization of high fluid strain micro contractions to study the stress on biological fluids

Francisco J. Tovar-Lopez; K. Khoshmanesh; M. Nasabi; Gary Rosengarten; Arnan Mitchell

doi:10.1117/12.813943

30 December 2008 Characterization of high fluid strain micro contractions to study the stress on biological fluids

Francisco J. Tovar-Lopez, K. Khoshmanesh, M. Nasabi, Gary Rosengarten, Arnan Mitchell

Proceedings Volume 7270, Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems; 72700H (2008) https://doi.org/10.1117/12.813943
Event: SPIE Smart Materials, Nano- and Micro-Smart Systems, 2008, Melbourne, Australia

Abstract

Microfluidics has the potential to enhance the understanding of the of biological fluids under strain, due to the laminar nature of the fluid and the possibility to mimic the real conditions. We present advances on characterization of a microfluidic platform to study high strain rate flows in the transport of biological fluids. These advances are improvements on the reproduction of a constant extensional strain rate using micro contractions and development of 3D numerical models. The micro geometries have been fabricated in polydimethyl siloxane (PDMS) using standard soft-lithography techniques with a photolithographically patterned mold. A comparison of some microcontractions with different funnel characteristics is presented. The Micro Particle Image Velocimetry technique has been applied to validate the numerical simulations. We demonstrate the use of microfluidics in the reproduction of a large range of controllable extensional strains that can be used in the study of the effect of flow on biological fluids.

Citation Download Citation

Francisco J. Tovar-Lopez, K. Khoshmanesh, M. Nasabi, Gary Rosengarten, and Arnan Mitchell "Characterization of high fluid strain micro contractions to study the stress on biological fluids", Proc. SPIE 7270, Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems, 72700H (30 December 2008); https://doi.org/10.1117/12.813943

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available