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28 October 2009 Low-power laser irradiation inhibits Aβ25-35-induced cell apoptosis through Akt activation
Zhigang Zhang, Yonghong Tang
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Proceedings Volume 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009); 75190T (2009) https://doi.org/10.1117/12.843560
Event: Photonics and Optoelectronics Meetings 2009, 2009, Wuhan, China
Abstract
Low-power laser irradiation (LPLI) can modulate various cellular processes such as proliferation, differentiation and apoptosis. Recently, LPLI has been applied to moderate Alzheimer's disease (AD), but the underlying mechanism remains unknown. The protective role of LPLI against the amyloid beta peptide (Aβ), a major constituent of AD plaques, has not been studied. PI3K/Akt pathway is extremely important in protecting cells from apoptosis caused by diverse stress stimuli. However, whether LPLI can inhibit Aβ-induced apoptosis through Akt activation is still unclear. In current study, using FRET (fluorescence resonance energy transfer) technique, we investigated the activity of Akt in response to LPLI treatment. B kinase activity reporter (BKAR), a recombinant FRET probe of Akt, was utilized to dynamically detect the activation of Akt after LPLI treatment. The results show that LPLI promoted the activation of Akt. Moreover, LPLI inhibits apoptosis induced by Aβ25-35 and the apoptosis inhibition can be abolished by wortmannin, a specific inhibitor of PI3K/Akt. Taken together, these results suggest that LPLI can inhibit Aβ25-35-induced cell apoptosis through Akt activation.
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Zhigang Zhang and Yonghong Tang "Low-power laser irradiation inhibits Aβ25-35-induced cell apoptosis through Akt activation", Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 75190T (28 October 2009); https://doi.org/10.1117/12.843560
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KEYWORDS
Cell death
Fluorescence resonance energy transfer
Luminescence
Laser irradiation
Proteins
Alzheimer's disease
Bandpass filters
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