Flicker stimulated retinal perfusion changes assessed with high-speed Doppler tomography

Tilman Schmoll; Amardeep S. G. Singh; Karine Frily; Cedric Blatter; Martin Villiger; Christoph Pache; Theo Lasser; R. A. Leitgeb

doi:10.1117/12.842922

2 March 2010 Flicker stimulated retinal perfusion changes assessed with high-speed Doppler tomography

Tilman Schmoll, Amardeep S. G. Singh, Karine Frily, Cedric Blatter, Martin Villiger, Christoph Pache, Theo Lasser, R. A. Leitgeb

Author Affiliations +

Proceedings Volume 7550, Ophthalmic Technologies XX; 75500F (2010) https://doi.org/10.1117/12.842922
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

We developed a high speed Doppler tomography system together with flow extraction algorithms that provide a flexible tool to assess retinal perfusion. The aim of the present study is to stimulate perfusion by flickering with light of adjustable color and to measure changes depending on light frequency and flicker location. We observed relative changes in arterial flow velocity during flicker stimulation up to 50%. We found in arteries close to the optic nerve head the highest flicker response at a frequency of 8Hz. We believe that a multimodal functional imaging concept is of high value for an accurate and early diagnosis and understanding of retinal pathologies and pathogenesis.

Citation Download Citation

Tilman Schmoll, Amardeep S. G. Singh, Karine Frily, Cedric Blatter, Martin Villiger, Christoph Pache, Theo Lasser, and R. A. Leitgeb "Flicker stimulated retinal perfusion changes assessed with high-speed Doppler tomography", Proc. SPIE 7550, Ophthalmic Technologies XX, 75500F (2 March 2010); https://doi.org/10.1117/12.842922

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