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The research work was carried out to study the effect of Oral and Intrathecal Monechma Ciliatum on antinociception and
EEG readings in Wistar Rats. Traditionally the extract is given to women in labour believed to reduce pain and ease
parturition, though past works show that it has oesteogenic and oxytotic effects. The rats were divided into 5 major
groups. Group 1 served as oral control group while groups 2 and 3 served as oral experimental groups and were treated
with 500mg/kg and 1000mg/kg monechma ciliatum respectively. Group 4 served as intrathecal control group treated
with intrathecal dextrose and group 5 received 1000mg/kg Monechma Ciliatrum intrathecally. The antinociceptive effect
was analysed using a Von Frey's aesthesiometer. Monechma Ciliatum showed significant antinociceptive effect both
orally and intrathecally, although it had a greater effect orally and during the first 15 minutes of intrathecal
administration. EEG readings were also taken for all the groups and there was a decrease in amplitude and an increase in
frequency for high dose (1000mg/ml) experimental groups and the mid brain electrodes produced a change from theta
waves (3.5 - 7 waves per second) to alpha waves (7.5 - 13 waves per second) as seen in relaxed persons and caused
decreased amplitudes and change in distribution seen in beta waves. Properties similarly accentuated by sedativehypnotic
drugs.
Ajibola B. Meraiyebu,Alexander B. Adelaiye, andOdeh S. O
"The antinociceptive effects of Monechma ciliatum and changes in EEG waves following oral and intrathecal administration in rats", Proc. SPIE 7552, Mechanisms for Low-Light Therapy V, 75520Q (4 March 2010); https://doi.org/10.1117/12.846101
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Ajibola B. Meraiyebu, Alexander B. Adelaiye, Odeh S. O, "The antinociceptive effects of Monechma ciliatum and changes in EEG waves following oral and intrathecal administration in rats," Proc. SPIE 7552, Mechanisms for Low-Light Therapy V, 75520Q (4 March 2010); https://doi.org/10.1117/12.846101