Healing and evaluating guinea pig skin incision after surgical suture and laser tissue by welding using in vivo Raman spectroscopy

A. Alimova; V. Sriramoju; R. Chakraverty; R. Muthukattil; R. R. Alfano

doi:10.1117/12.842190

25 February 2010 Healing and evaluating guinea pig skin incision after surgical suture and laser tissue by welding using in vivo Raman spectroscopy

A. Alimova, V. Sriramoju, R. Chakraverty, R. Muthukattil, R. R. Alfano

Author Affiliations +

Proceedings Volume 7561, Optical Biopsy VII; 756114 (2010) https://doi.org/10.1117/12.842190
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Changes in collagen in the wound during the healing process of guinea pig skin following surgical incisions and LTW was evaluated using in vivo, using Raman spectroscopy. Raman spectroscopy provided information regarding the internal structure of the proteins. After the incisions were closed either by suturing or by LTW the ratio of the Raman peaks of the amide III (1247 cm^-1) band to a peak at 1326 cm^-1 used to evaluate the progression of collagen deposition. Histopathology was used as the gold standard. LTW skin demonstrated better healing than sutured skin, exhibiting minimal hyperkeratosis, minimal collagen deposition, near-normal surface contour, and minimal loss of dermal appendages. This work is important to plastic surgery.

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A. Alimova, V. Sriramoju, R. Chakraverty, R. Muthukattil, and R. R. Alfano "Healing and evaluating guinea pig skin incision after surgical suture and laser tissue by welding using in vivo Raman spectroscopy", Proc. SPIE 7561, Optical Biopsy VII, 756114 (25 February 2010); https://doi.org/10.1117/12.842190

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KEYWORDS

Skin

Raman spectroscopy

Collagen

Tissues

Laser tissue interaction

In vivo imaging

Laser welding

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