Combined optical coherence tomography based on the extended Huygens-Fresnel principle and histology of mouse skin

Shulian Wu; Zhifang Li; Hui Li; Xianghua Shi

doi:10.1117/12.841415

25 February 2010 Combined optical coherence tomography based on the extended Huygens-Fresnel principle and histology of mouse skin

Shulian Wu, Zhifang Li, Hui Li, Xianghua Shi

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Proceedings Volume 7568, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VIII; 756820 (2010) https://doi.org/10.1117/12.841415
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Noninvasive measurement technique to obtain tissue optical properties such as the scattering coefficient μs and the anisotropy factor g using optical coherence tomography (OCT) scattering model which based on the Extended Huygens-Fresnel principle is developed in our paper. Older and younger mouse-skin are as animal model to compare its scattering coefficient μs and the anisotropy factor g, the outcome shows that scattering coefficient μs is increased with the age of mouse-skin. Furthermore, we have made age's mouse-skin into H.E stain slices; the result of its morphology is consistent with the OCT imaging and OCT-EHF principle. All of that have provided the theoretical basis which to the research on photo-aging skin and photo-rejuvenation.

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Shulian Wu, Zhifang Li, Hui Li, and Xianghua Shi "Combined optical coherence tomography based on the extended Huygens-Fresnel principle and histology of mouse skin", Proc. SPIE 7568, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VIII, 756820 (25 February 2010); https://doi.org/10.1117/12.841415

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KEYWORDS

Optical coherence tomography

Scattering

Skin

Anisotropy

Collagen

Tissues

Laser scattering

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