Micro-tattoo guided OCT imaging of site specific inflammation

Kevin G. Phillips; Niloy Choudhury; Ravikant V. Samatham; Harvinder Singh; Steven L. Jacques

doi:10.1117/12.842570

26 February 2010 Micro-tattoo guided OCT imaging of site specific inflammation

Kevin G. Phillips, Niloy Choudhury, Ravikant V. Samatham, Harvinder Singh, Steven L. Jacques

Proceedings Volume 7573, Biomedical Applications of Light Scattering IV; 75730S (2010) https://doi.org/10.1117/12.842570
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Epithelial biologists studying human skin diseases such as cancer formation and psoriasis commonly utilize mouse models to characterize the interplay among cells and intracellular signal transduction pathways that result in programmed changes in gene expression and cellular behaviors. The information obtained from animal models is useful only when phenotypic presentations of disease recapitulate those observed in humans. Excision of tissues followed by histochemical analysis is currently the primary means of establishing the morphological presentation. Non invasive imaging of animal models provides an alternate means to characterize tissue morphology associated with the disease of interest in vivo. While useful, the ability to perform in vivo imaging at different time points in the same tissue location has been a challenge. This information is key to understanding site specific changes as the imaged tissue can now be extracted and analyzed for mRNA expression. We present a method employing a micro-tattoo to guide optical coherence tomography (OCT) imaging of ultraviolet induced inflammation over time in the same tissue locations.

Citation Download Citation

Kevin G. Phillips, Niloy Choudhury, Ravikant V. Samatham, Harvinder Singh, and Steven L. Jacques "Micro-tattoo guided OCT imaging of site specific inflammation", Proc. SPIE 7573, Biomedical Applications of Light Scattering IV, 75730S (26 February 2010); https://doi.org/10.1117/12.842570

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