Plasmon resonance gold nanoparticles for improving optical diagnostics and photothermal therapy of tumor

E. V. Zagainova; M. A. Sirotkina; M. V. Shirmanova; V. V. Elagin; M. Kirillin; P. Agrba; V. A. Kamensky; V. A. Nadtochenko

doi:10.1117/12.840638

16 February 2010 Plasmon resonance gold nanoparticles for improving optical diagnostics and photothermal therapy of tumor

E. V. Zagainova, M. A. Sirotkina, M. V. Shirmanova, V. V. Elagin, M. Kirillin, P. Agrba, V. A. Kamensky, V. A. Nadtochenko

Author Affiliations +

Proceedings Volume 7577, Plasmonics in Biology and Medicine VII; 75770P (2010) https://doi.org/10.1117/12.840638
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

The study was performed on 16 CBA-line female mice with transplanted cervical cancer. 0.2 ml of gold nanoparticle solution with a concentration of 10⁹ particles/ml were injected into the animals intravenously. The particles were 200-250 nm in size; the plasmon-resonance related extinction maximum was at the wavelength of 850-950 nm. Accumulation of the nanoparticles into tumor node was visualized by the method of optical coherence tomography (OCT). When the accumulation of nanoparticles in the tumor was maximal, hyperthermia was accomplished using the LSP-AZOR laser setup generating cw radiation at 810 nm. The duration of exposition was 20 min. The therapeutical effect was assessed by the rate of tumor growth inhibition (TGI, %). Determining the instant when nanoparticle concentration in tumor tissue reaches its maximum enables more efficient laser impact. The use of nanoparticles decreases laser irradiation power and ensures local action.

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E. V. Zagainova, M. A. Sirotkina, M. V. Shirmanova, V. V. Elagin, M. Kirillin, P. Agrba, V. A. Kamensky, and V. A. Nadtochenko "Plasmon resonance gold nanoparticles for improving optical diagnostics and photothermal therapy of tumor", Proc. SPIE 7577, Plasmonics in Biology and Medicine VII, 75770P (16 February 2010); https://doi.org/10.1117/12.840638

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KEYWORDS

Tumors

Nanoparticles

Optical coherence tomography

Gold

Tissues

Skin

Particles

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