Real-time spectroscopic evaluation of oral lesions and comparisons with histopathology

Richard A. Schwarz; Wen Gao; Jennifer Nguyen; Nadarajah Vigneswaran; Karen Adler-Storthz; Vijayashree S. Bhattar; Michelle D. Williams M.D.; Ann M. Gillenwater M.D.; Rebecca Richards-Kortum

doi:10.1117/12.887758

17 February 2011 Real-time spectroscopic evaluation of oral lesions and comparisons with histopathology

Richard A. Schwarz, Wen Gao, Jennifer Nguyen, Nadarajah Vigneswaran, Karen Adler-Storthz, Vijayashree S. Bhattar, Michelle D. Williams M.D., Ann M. Gillenwater M.D., Rebecca Richards-Kortum

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Proceedings Volume 7883, Photonic Therapeutics and Diagnostics VII; 78832K (2011) https://doi.org/10.1117/12.887758
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Optical techniques including widefield autofluorescence and reflectance imaging, depth-sensitive optical spectroscopy, and high-resolution imaging can be used to noninvasively detect dysplastic and cancerous alterations in oral tissue. The diagnostic performance of depth-sensitive optical spectroscopy with respect to histopathology is examined. A compact, portable spectroscopy device for clinical use is described. Practical considerations for the comparison of optical measurements to histopathologic diagnoses are outlined. Important considerations for comparison to histopathology include the physical correspondence of the measured region to the biopsy or specimen; data collection and processing procedures; and data analysis procedures. Multimodal combinations of widefield imaging, point spectroscopy, and highresolution imaging may enhance the ability of clinicians to accurately assess the margins of neoplastic oral lesions in vivo.

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Richard A. Schwarz, Wen Gao, Jennifer Nguyen, Nadarajah Vigneswaran, Karen Adler-Storthz, Vijayashree S. Bhattar, Michelle D. Williams M.D., Ann M. Gillenwater M.D., and Rebecca Richards-Kortum "Real-time spectroscopic evaluation of oral lesions and comparisons with histopathology", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78832K (17 February 2011); https://doi.org/10.1117/12.887758

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KEYWORDS

Imaging spectroscopy

Optical testing

Spectroscopy

Tissue optics

Pathology

Biopsy

Diagnostics

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