Time resolved optical system for an early detection of prostate tumor

Lionel Hervé; Aurélie Laidevant; Mathieu Debourdeau; Jérôme Boutet; Jean-Marc Dinten

doi:10.1117/12.874575

1 March 2011 Time resolved optical system for an early detection of prostate tumor

Lionel Hervé, Aurélie Laidevant, Mathieu Debourdeau, Jérôme Boutet, Jean-Marc Dinten

Proceedings Volume 7896, Optical Tomography and Spectroscopy of Tissue IX; 789622 (2011) https://doi.org/10.1117/12.874575
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

We developed an endorectal time-resolved optical probe aiming at an early detection of prostate tumors targeted by fluorescent markers. Optical fibers are embedded inside a clinical available ultrasound endorectal probe. Excitation light is driven sequentially from a femtosecond laser (775 nm) into 6 source fibers. 4 detection fibers collect the medium responses at the excitation and fluorescence wavelength (850 nm) by the mean of 4 photomultipliers associated with a 4 channel time-correlated single photon counting card. We also developed the method to process the experimental data. This involves the numerical computation of the forward model, the creation of robust features which are automatically correctly from numerous experimental possible biases and the reconstruction of the inclusion by using the intensity and mean time of these features. To evaluate our system performance, we acquired measurements of a 40 μL ICG inclusion (10 μmol.L^-1) at various lateral and depth locations in a phantom. Analysis of results showed we correctly reconstructed the fluorophore for the lateral positions (16 mm range) and for a distance to the probe going up to 1.5 cm. Precision of localization was found to be around 1 mm which complies well with precision specifications needed for the clinical application.

Citation Download Citation

Lionel Hervé, Aurélie Laidevant, Mathieu Debourdeau, Jérôme Boutet, and Jean-Marc Dinten "Time resolved optical system for an early detection of prostate tumor", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 789622 (1 March 2011); https://doi.org/10.1117/12.874575

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KEYWORDS

Luminescence

Optical fibers

Prostate

Sensors

Tumors

Light

Diffusion

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