3D tomographic breast imaging [i]in-vivo[/i] using a handheld optical imager

Sarah J. Erickson; Sergio Martinez; Jean Gonzalez; Manuela Roman; Annie Nunez; Anuradha Godavarty

doi:10.1117/12.874347

17 February 2011 3D tomographic breast imaging in-vivo using a handheld optical imager

Sarah J. Erickson, Sergio Martinez, Jean Gonzalez, Manuela Roman, Annie Nunez, Anuradha Godavarty

Proceedings Volume 7896, Optical Tomography and Spectroscopy of Tissue IX; 78962H (2011) https://doi.org/10.1117/12.874347
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Hand-held optical imagers are currently developed toward clinical imaging of breast tissue. However, the hand-held optical devices developed to are not able to coregister the image to the tissue geometry for 3D tomography. We have developed a hand-held optical imager which has demonstrated automated coregistered imaging and 3D tomography in phantoms, and validated coregistered imaging in normal human subjects. Herein, automated coregistered imaging is performed in a normal human subject with a 0.45 cm³ spherical target filled with 1 μM indocyanine green (fluorescent contrast agent) placed superficially underneath the flap of the breast tissue. The coregistered image data is used in an approximate extended Kalman filter (AEKF) based reconstruction algorithm to recover the 3D location of the target within the breast tissue geometry. The results demonstrate the feasibility of performing 3D tomographic imaging and recovering a fluorescent target in breast tissue of a human subject for the first time using a hand-held based optical imager. The significance of this work is toward clinical imaging of breast tissue for cancer diagnostics and therapy monitoring.

Citation Download Citation

Sarah J. Erickson, Sergio Martinez, Jean Gonzalez, Manuela Roman, Annie Nunez, and Anuradha Godavarty "3D tomographic breast imaging in-vivo using a handheld optical imager", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78962H (17 February 2011); https://doi.org/10.1117/12.874347

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