Optical-resolution photoacoustic microscopy of ischemic stroke

Song Hu; Ernie Gonzales; Brian Soetikno; Enhao Gong; Ping Yan; Konstantin Maslov; Jin-Moo Lee; Lihong V. Wang

doi:10.1117/12.874366

10 February 2011 Optical-resolution photoacoustic microscopy of ischemic stroke

Song Hu, Ernie Gonzales, Brian Soetikno, Enhao Gong, Ping Yan, Konstantin Maslov, Jin-Moo Lee, Lihong V. Wang

Proceedings Volume 7899, Photons Plus Ultrasound: Imaging and Sensing 2011; 789906 (2011) https://doi.org/10.1117/12.874366
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

A major obstacle in understanding the mechanism of ischemic stroke is the lack of a tool to noninvasively or minimally invasively monitor cerebral hemodynamics longitudinally. Here, we applied optical-resolution photoacoustic microscopy (OR-PAM) to longitudinally study ischemic stroke induced brain injury in a mouse model with transient middle cerebral artery occlusion (MCAO). OR-PAM showed that, during MCAO, the average hemoglobin oxygen saturation (sO₂) values of feeder arteries and draining veins within the stroke core region dropped ~10% and ~34%, respectively. After reperfusion, arterial sO₂ recovered back to the baseline; however, the venous sO2 increased above the baseline value by ~7%. Thereafter, venous sO₂ values were close to the arterial sO₂ values, suggesting eventual brain tissue infarction.

Citation Download Citation

Song Hu, Ernie Gonzales, Brian Soetikno, Enhao Gong, Ping Yan, Konstantin Maslov, Jin-Moo Lee, and Lihong V. Wang "Optical-resolution photoacoustic microscopy of ischemic stroke", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789906 (10 February 2011); https://doi.org/10.1117/12.874366

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