Selective vapor phase sensing of small molecules using biofunctionalized field effect transistors

Joshua A. Hagen; Sang Nyon Kim; Nancy Kelley-Loughnane; Rajesh R. Naik; Morley O. Stone

doi:10.1117/12.882119

3 June 2011 Selective vapor phase sensing of small molecules using biofunctionalized field effect transistors

Joshua A. Hagen, Sang Nyon Kim, Nancy Kelley-Loughnane, Rajesh R. Naik, Morley O. Stone

Proceedings Volume 8018, Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XII; 80180B (2011) https://doi.org/10.1117/12.882119
Event: SPIE Defense, Security, and Sensing, 2011, Orlando, Florida, United States

Abstract

This work details a proof of concept study for vapor phase selective sensing using a strategy of biorecognition elements (BRE) integrated into a zinc oxide field effect transistor (ZnO FET). ZnO FETs are highly sensitive to changes to the environment with little to no selectivity. Addition of a biorecognition element retains the sensitivity of the device while adding selectivity. The DNA aptamer designed to bind the small molecule riboflavin was covalently integrated into the ZnO FET and detects the presence of 116 ppb of riboflavin in a nitrogen atmosphere by a change in current. The unfunctionalized ZnO FET shows no response to this same concentrations of riboflavin, showing that the aptamerbinding strategy may be a promising strategy for vapor phase sensing.

Citation Download Citation

Joshua A. Hagen, Sang Nyon Kim, Nancy Kelley-Loughnane, Rajesh R. Naik, and Morley O. Stone "Selective vapor phase sensing of small molecules using biofunctionalized field effect transistors", Proc. SPIE 8018, Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XII, 80180B (3 June 2011); https://doi.org/10.1117/12.882119

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available