Contrast-enhanced diffuse optical tomography of brain perfusion in humans using ICG

Christina Habermehl; Christoph Schmitz; Jens Steinbrink

doi:10.1117/12.905742

9 February 2012 Contrast-enhanced diffuse optical tomography of brain perfusion in humans using ICG

Christina Habermehl, Christoph Schmitz, Jens Steinbrink

Proceedings Volume 8207, Photonic Therapeutics and Diagnostics VIII; 82074O (2012) https://doi.org/10.1117/12.905742
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Regular monitoring of brain perfusion at the bedside in neurointensive care is desirable. Currently used imaging modalities are not suited for constant monitoring and often require a transport of the patient. Noninvasive near infrared spectroscopy (NIRS) in combination with an injection of a safe dye (indocyanine green, ICG) could serve as a quasi-continuous brain perfusion monitor. In this work, we evaluate prerequisites for the development of a brain perfusion monitor using continuous wave (cw) NIRS technique. We present results from a high-resolution diffuse optical tomography (HR-DOT) experiment in humans demonstrating the separation of signals from skin from the brain. This technique can help to monitor neurointensive care patients on a regular basis, detecting changes in cortical perfusion in time.

Citation Download Citation

Christina Habermehl, Christoph Schmitz, and Jens Steinbrink "Contrast-enhanced diffuse optical tomography of brain perfusion in humans using ICG", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82074O (9 February 2012); https://doi.org/10.1117/12.905742

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