Influence of hemoglobin on non-invasive optical bilirubin sensing

Jingying Jiang; Qiliang Gong; Da Zou; Kexin Xu

doi:10.1117/12.906509

9 February 2012 Influence of hemoglobin on non-invasive optical bilirubin sensing

Jingying Jiang, Qiliang Gong, Da Zou, Kexin Xu

Proceedings Volume 8222, Dynamics and Fluctuations in Biomedical Photonics IX; 822218 (2012) https://doi.org/10.1117/12.906509
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Since the abnormal metabolism of bilirubin could lead to diseases in the human body, especially the jaundice which is harmful to neonates. Traditional invasive measurements are difficult to be accepted by people because of pain and infection. Therefore, the real-time and non-invasive measurement of bilirubin is of great significance. However, the accuracy of currently transcutaneous bilirubinometry(TcB) is generally not high enough, and affected by many factors in the human skin, mostly by hemoglobin. In this talk, absorption spectra of hemoglobin and bilirubin have been collected and analyzed, then the Partial Least Squares (PLS) models have been built. By analyzing and comparing the Correlation and Root Mean Square Error of Prediction(RMSEP), the results show that the Correlation of bilirubin solution model is larger than that of the mixture solution added with hemoglobin, and its RMSEP value is smaller than that of mixture solution. Therefore, hemoglobin has influences on the non-invasive optical bilirubin sensing. In next step, it is necessary to investigate how to eliminate the influence.

Citation Download Citation

Jingying Jiang, Qiliang Gong, Da Zou, and Kexin Xu "Influence of hemoglobin on non-invasive optical bilirubin sensing", Proc. SPIE 8222, Dynamics and Fluctuations in Biomedical Photonics IX, 822218 (9 February 2012); https://doi.org/10.1117/12.906509

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Data modeling

Absorption

Optical sensing

Chemical analysis

Absorbance

Biomedical optics

Blood

Show All Keywords

Keywords/Phrases

Search In:

Publication Years