Simultaneous in vivo imaging of melanin and lipofuscin in the retina with multimodal photoacoustic ophthalmoscopy

Xiangyang Zhang; Hao F. Zhang; Lixiang Zhou; Shuliang Jiao

doi:10.1117/12.908820

23 February 2012 Simultaneous in vivo imaging of melanin and lipofuscin in the retina with multimodal photoacoustic ophthalmoscopy

Xiangyang Zhang, Hao F. Zhang, Lixiang Zhou, Shuliang Jiao

Author Affiliations +

Proceedings Volume 8223, Photons Plus Ultrasound: Imaging and Sensing 2012; 822305 (2012) https://doi.org/10.1117/12.908820
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

We combined photoacoustic ophthalmoscopy (PAOM) with autofluorescence imaging for simultaneous in vivo imaging of dual molecular contrasts in the retina using a single light source. The dual molecular contrasts come from melanin and lipofuscin in the retinal pigment epithelium (RPE). Melanin and lipofuscin are two types of pigments and are believed to play opposite roles (protective vs. exacerbate) in the RPE in the aging process. We successfully imaged the retina of pigmented and albino rats at different ages. The experimental results showed that multimodal PAOM system can be a potentially powerful tool in the study of age-related degenerative retinal diseases.

Citation Download Citation

Xiangyang Zhang, Hao F. Zhang, Lixiang Zhou, and Shuliang Jiao "Simultaneous in vivo imaging of melanin and lipofuscin in the retina with multimodal photoacoustic ophthalmoscopy", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 822305 (23 February 2012); https://doi.org/10.1117/12.908820

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KEYWORDS

Atrial fibrillation

Retina

In vivo imaging

Photoacoustic spectroscopy

Ophthalmoscopy

Signal detection

Optical filters

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