Novel optoacoustic system for noninvasive continuous monitoring of cerebral venous blood oxygenation

Yuriy Petrov; Irene Y. Petrov; Donald S. Prough; Rinat O. Esenaliev

doi:10.1117/12.914650

28 February 2012 Novel optoacoustic system for noninvasive continuous monitoring of cerebral venous blood oxygenation

Yuriy Petrov, Irene Y. Petrov, Donald S. Prough, Rinat O. Esenaliev

Proceedings Volume 8223, Photons Plus Ultrasound: Imaging and Sensing 2012; 82231L (2012) https://doi.org/10.1117/12.914650
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Traumatic brain injury (TBI) and spinal cord injury are a major cause of death for individuals under 50 years of age. In the USA alone, 150,000 patients per year suffer moderate or severe TBI. Moreover, TBI is a major cause of combatrelated death. Monitoring of cerebral venous blood oxygenation is critically important for management of TBI patients because cerebral venous blood oxygenation below 50% results in death or severe neurologic complications. At present, there is no technique for noninvasive, accurate monitoring of this clinically important variable. We proposed to use optoacoustic technique for noninvasive monitoring of cerebral venous blood oxygenation by probing cerebral veins such as the superior sagittal sinus (SSS) and validated it in animal studies. In this work, we developed a novel, medical grade optoacoustic system for continuous, real-time cerebral venous blood oxygenation monitoring and tested it in human subjects at normal conditions and during hyperventilation to simulate changes that may occur in patients with TBI. We designed and built a highly-sensitive optoacoustic probe for SSS signal detection. Continuous measurements were performed in the near infrared spectral range and the SSS oxygenation absolute values were automatically calculated in real time using a special algorithm developed by our group. Continuous measurements performed at normal conditions and during hyperventilation demonstrated that hyperventilation resulted in approximately 12% decrease of cerebral venous blood oxygenation.

Citation Download Citation

Yuriy Petrov, Irene Y. Petrov, Donald S. Prough, and Rinat O. Esenaliev "Novel optoacoustic system for noninvasive continuous monitoring of cerebral venous blood oxygenation", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82231L (28 February 2012); https://doi.org/10.1117/12.914650

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available